peptideInjectable
SS-31
Also known as: Elamipretide, Bendavia
Half-life
4 h
Typical timing
any
Food rule
either
Default unit
mg
Studied for
Overview
SS-31, also known as Elamipretide or Bendavia, is a synthetic tetrapeptide that has garnered significant interest for its targeted action on mitochondria. Specifically, SS-31 interacts with cardiolipin, a phospholipid found in the inner mitochondrial membrane, which is crucial for mitochondrial health and function. This interaction is believed to stabilize the inner mitochondrial membrane and protect against oxidative damage.
The peptide's structure, D-Arg-Dmt-Lys-Phe-NH2, allows it to readily cross biological membranes, including the blood-brain barrier, and accumulate within the mitochondria. This selective targeting is central to its proposed mechanisms of action in mitigating mitochondrial dysfunction, which is implicated in various age-related diseases and conditions of cellular stress. SS-31 is currently under investigation in clinical trials for several indications, reflecting its potential as a therapeutic agent (NIH Clinical Trials Registry, DrugBank).
Deep dive
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Known interactions
- Category rule: peptide × hormoneNote
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
Sources referenced
* NIH Clinical Trials Registry
* DrugBank
* PubChem
* Examine.com
* Cochrane Library
* NIH Office of Dietary Supplements (referencing related research)
* MedlinePlus
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
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Related benefits
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