Methylene Blue (MB) is a synthetic organic compound that belongs to the phenothiazine class. It is perhaps best known for its historical use as a dye for staining tissues and bacteria, and as a treatment for methemoglobinemia. However, in recent decades, research has expanded its potential applications, particularly in the fields of neuroscience and mitochondrial health. It is characterized by its deep blue color in solution.
MB has a wide range of biological activities, acting as an electron carrier within the mitochondria, an antioxidant, and a modulator of various signaling pathways. It has been investigated for its potential neuroprotective effects, cognitive enhancement, and anti-aging properties. While Methylene Blue is available as a supplement, it is also used as a prescription medication for specific medical conditions. It is important to distinguish between these uses and to understand that the information provided here pertains to its general properties and research, and not to specific medical treatments.
Deep dive
Tap a section to expand.
Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Frequently asked
Sources referenced
["PubChem (National Center for Biotechnology Information)", "DrugBank Online", "FDA label (for medical grade Methylene Blue)", "EMA SmPC (European Medicines Agency Summary of Product Characteristics)", "MedlinePlus (National Library of Medicine)", "NIH Office of Dietary Supplements (general information on dietary supplements)"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.