Nicotinamide Riboside (NR), often referred to by its brand name Niagen, is a naturally occurring form of vitamin B3 (niacin) that serves as a precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ is a coenzyme crucial for various fundamental biological processes, including energy metabolism, DNA repair, and cellular signaling. Unlike other forms of vitamin B3 such as nicotinic acid and nicotinamide, NR is thought to convert into NAD+ with distinct metabolic pathways. It is found in trace amounts in some foods, including milk and some yeasts, and is widely available as a dietary supplement. Interest in NR as a supplement stems from its capacity to elevate NAD+ levels within cells, which tend to decline with age. Research into NR's effects spans areas such as cellular energy, metabolic health, and the aging process (Examine.com, NIH ODS).
Deep dive
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Known interactions
Compound-pair rule
Note
Both are NAD+ precursors, so taking both is largely redundant.
Usually pick one.
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Compound-pair rule
Note
Both raise NAD+ via similar pathway; stacking rarely additive.
Choose one NAD+ precursor rather than layering both.
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
