Nicotinamide mononucleotide (NMN) is a naturally occurring compound that serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a vital coenzyme found in all living cells. NAD+ plays a crucial role in numerous biological processes, including energy metabolism, DNA repair, and gene expression.
NMN can be synthesized in the body from B vitamins and is also present in small amounts in various food sources such as broccoli, cabbage, cucumbers, avocados, and various fruits. As a supplement, NMN is often marketed for its potential in promoting healthy aging and supporting cellular function by increasing NAD+ levels. Research into NMN's effects is ongoing, with studies exploring its implications in various physiological systems. (PubChem, NIH ODS)
Deep dive
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Known interactions
Compound-pair rule
Note
Both are NAD+ precursors, so taking both is largely redundant.
Usually pick one.
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Compound-pair rule
Note
Both raise NAD+ via similar pathway; stacking rarely additive.
Choose one NAD+ precursor rather than layering both.
Sources referenced
- PubChem
- NIH Office of Dietary Supplements (ODS)
- DrugBank
- Mayo Clinic
- Examine.com
- Cochrane Library
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
