Urolithin A is a natural postbiotic compound produced by gut bacteria from ellagitannins, which are found in pomegranates, berries, and nuts. It is not directly present in foods but is formed by the microbial conversion of these dietary precursors in the gut.
Interest in Urolithin A has grown due to its potential role in cellular health, particularly its association with mitochondrial function and cellular recycling processes. It is often marketed and studied for its implications in healthy aging and muscle support.
Urolithin A has a half-life of approximately 17 hours in humans, meaning it takes about 17 hours for half of the compound to be eliminated from the body after absorption. This relatively long half-life contributes to sustained levels in the system. The compound is commonly available as a dietary supplement, sometimes under brand names such as Mitopure.
While research is ongoing, initial studies suggest Urolithin A may support cellular processes that diminish with age, making it relevant to discussions around longevity and metabolic health. (Source: PubChem, Examine.com)
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Frequently asked
Sources referenced
* PubChem (National Library of Medicine)
* Examine.com
* NIH Office of Dietary Supplements (ODS)
* Mayo Clinic
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
