hormone

Pregnenolone

Chemical structure of Pregnenolone (PubChem CID 8955)
Structure via PubChem
Half-life
12 h
Typical timing
morning
Food rule
either
Default unit
mg

Studied for

Overview

Pregnenolone is an endogenous steroid hormone that serves as a precursor for many other steroid hormones in the body, including progesterone, DHEA, androgens (like testosterone), and estrogens. It is synthesized primarily from cholesterol within the adrenal glands, gonads, brain, and other tissues. Due to its role as a "mother hormone," pregnenolone is involved in a wide range of physiological processes. While naturally produced, it is also available as a dietary supplement. Interest in pregnenolone stems from its potential roles in neurosteroid activity and hormone balance, particularly as levels may decline with age (NIH ODS).

Deep dive

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Known interactions

  • Category rule: peptide × hormone
    Note

    Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.

    Track bloodwork with a provider; don't assume combinations are neutral.

Frequently asked

Sources referenced

["Cochrane","DrugBank","Examine.com","Mayo Clinic","MedlinePlus","NIH Office of Dietary Supplements (ODS)","PubChem"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

Others in the hormone category or studied for the same goals.

Related benefits

Other compounds studied for the same benefits as Pregnenolone.

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