supplement

Alpha-GPC

Also known as: Choline alfoscerate

Half-life
4 h
Typical timing
morning
Food rule
either
Default unit
mg

Studied for

Overview

Alpha-GPC (L-Alpha glycerylphosphorylcholine or Choline alfoscerate) is a naturally occurring choline compound found in the brain and in some foods such as soy and milk. It is also marketed as a dietary supplement. Alpha-GPC is distinct from other choline sources because it is a phospholipid metabolite, meaning it is derived from fats and can readily cross the blood-brain barrier. Often utilized for its potential cognitive benefits, Alpha-GPC serves as a precursor for the neurotransmitter acetylcholine, which plays a critical role in memory, learning, and other cognitive functions. It is also involved in the structural integrity of cell membranes. (NIH ODS, PubChem)

Deep dive

Tap a section to expand.

Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

  • Compound-pair rule
    Synergy

    Racetams increase acetylcholine turnover; adding a choline source can prevent headaches from choline depletion.

    Consider stacking 300–600 mg alpha-GPC with racetam doses.

  • Compound-pair rule
    Synergy

    Racetam + choline source stack is well-established for cognition and headache prevention.

    Add alpha-GPC 300 mg with each aniracetam dose.

Frequently asked

Sources referenced

["NIH Office of Dietary Supplements (ODS)", "MedlinePlus", "PubChem", "Mayo Clinic", "Examine.com", "DrugBank", "Cochrane Library"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

Others in the supplement category or studied for the same goals.

Related benefits

Other compounds studied for the same benefits as Alpha-GPC.

Continue exploring

See every compound Stackwise catalogues for these goals.

Track Alpha-GPC in Stackwise

Add it to your stack. We'll schedule doses, check interactions against everything else you take, and remind you at the right time.

Sign up free →