Amphetamine salts are a central nervous system (CNS) stimulant medication primarily used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It works by increasing the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine, which can improve focus, attention, and impulse control in individuals with ADHD, and help manage excessive daytime sleepiness in narcolepsy. The medication is available in immediate-release and extended-release formulations, which affects how quickly and for how long the effects are felt. Given its controlled status, amphetamine salts are prescribed and monitored by a licensed clinician. (FDA label, DrugBank)
Deep dive
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Limit caffeine when using prescription stimulants; monitor blood pressure.
Compound-pair rule
Avoid
Yohimbine + stimulants sharply increases sympathetic tone and can trigger arrhythmia.
Do not combine.
Frequently asked
Sources referenced
["U.S. Food and Drug Administration (FDA) Label Information", "DrugBank", "National Institutes of Health (NIH) MedlinePlus", "Mayo Clinic", "Cochrane Library Summaries", "U.S. Drug Enforcement Administration (DEA)"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
