peptideInjectable
Modified GRF (1-29)
Also known as: Mod GRF, CJC-1295 no-DAC
Half-life
0.5 h
Typical timing
bedtime
Food rule
either
Default unit
mcg
Studied for
Overview
Modified GRF (1-29), often referred to as Mod GRF or CJC-1295 no-DAC, is a synthetic peptide based on the naturally occurring growth hormone-releasing hormone (GHRH). It is a truncated analog of GHRH, specifically encompassing the first 29 amino acids of the GHRH sequence. The 'modified' aspect refers to specific amino acid substitutions designed to enhance its stability and activity within the body compared to standard GHRH (source: PubChem). Unlike CJC-1295 with DAC (Drug Affinity Complex), Mod GRF (1-29) does not incorporate the DAC component, which significantly impacts its pharmacokinetics and half-life. Mod GRF (1-29) is typically administered via subcutaneous injection (source: reputable peptide research supply descriptions). It has been investigated for its potential to stimulate the pulsatile release of growth hormone from the pituitary gland. This stimulation is transient due to its relatively short half-life.
Deep dive
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Known interactions
- Category rule: peptide × hormoneNote
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
Frequently asked
Sources referenced
- PubChem
- NIH National Institute of Diabetes and Digestive and Kidney Diseases
- MedlinePlus
- Mayo Clinic
- Cochrane Library
- DrugBank
- Endocrine Society Guidelines
- General Pharmacology and Endocrinology Textbooks
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
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