Ashwagandha (Withania somnifera) is an adaptogenic herb widely used in Ayurvedic medicine for centuries. KSM-66 is a branded, full-spectrum extract of ashwagandha root, standardized to a high concentration of total withanolides. The extraction process for KSM-66 reportedly uses a 'green chemistry' approach without alcohol or synthetic solvents, aiming to maintain the natural balance of constituents found in the raw root. It is often marketed for its potential in stress reduction, cognitive support, and overall well-being. Unlike some other ashwagandha extracts, KSM-66 focuses on retaining both hydrophilic and lipophilic components of the root. The half-life of relevant compounds from ashwagandha in the human body can vary, but some studies indicate a half-life of approximately 7 hours for certain active constituents.
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Compound-pair rule
Note
May raise thyroid hormone; can amplify levothyroxine effect.
Monitor TSH when combining.
Frequently asked
Sources referenced
["Examine.com", "National Institutes of Health (NIH) Office of Dietary Supplements (ODS)", "MedlinePlus", "PubChem", "Cochrane Library"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.