peptideInjectable

GHRP-2

Chemical structure of GHRP-2 (PubChem CID 6918245)
Structure via PubChem
Half-life
0.3 h
Typical timing
bedtime
Food rule
either
Default unit
mcg

Studied for

Overview

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide that acts as a potent secretagogue for growth hormone (GH) from the pituitary gland. It functions as a ghrelin mimetic, binding to the ghrelin receptor (also known as the GHS-R1a receptor) to stimulate both the release of GH and, to a lesser extent, prolactin and ACTH. Unlike GHRH (Growth Hormone Releasing Hormone), which primarily targets somatotrophs in the pituitary, GHRP-2 works through a distinct mechanism by increasing intracellular calcium levels and activating signaling pathways that lead to pulsatile GH secretion. This dual action on GH release, both directly at the pituitary and by modulating hypothalamic somatostatin (an inhibitor of GH release), makes GHRP-2 a robust stimulator of growth hormone. It is a research chemical and is not approved by regulatory bodies like the FDA for human therapeutic use.

Deep dive

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Known interactions

  • Category rule: peptide × hormone
    Note

    Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.

    Track bloodwork with a provider; don't assume combinations are neutral.

Frequently asked

Sources referenced

["DrugBank (DB09100)"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

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Related benefits

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