Modafinil, marketed under the brand name Provigil, is a medication primarily prescribed to improve wakefulness in adults who experience excessive sleepiness due to certain sleep disorders. It is classified as a wakefulness-promoting agent. Approved by the U.S. Food and Drug Administration (FDA), its primary indications include narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder (SWSD). While it promotes wakefulness, its pharmacological profile differs from traditional stimulants such as amphetamines. It is a controlled substance due to its potential for misuse and dependence. (FDA label, DrugBank)
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Frequently asked
Sources referenced
- U.S. Food and Drug Administration (FDA) label for Provigil
- DrugBank
- PubChem
- MedlinePlus
- Mayo Clinic
- National Institute of Neurological Disorders and Stroke (NINDS)
- American Academy of Sleep Medicine (AASM)
- Cochrane Library
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
