5-Amino-1MQ, also known as 5-Amino-1-methylquinolinium, is a small molecule that has garnered interest in preclinical research due to its potential cellular effects. It is primarily studied for its impact on nicotinamide N-methyltransferase (NNMT), an enzyme found in various tissues, including adipose (fat) tissue, liver, and muscle. NNMT plays a role in cellular metabolism by regulating the levels of S-adenosylmethionine (SAM) and nicotinamide adenine dinucleotide (NAD+), two important cofactors involved in numerous biological processes. By inhibiting NNMT, 5-Amino-1MQ is hypothesized to influence cellular energy expenditure and metabolic pathways. This compound is not an approved medication and is primarily encountered in research settings or as a supplement. It is important to note that much of the current understanding of 5-Amino-1MQ comes from in vitro and animal studies, and human research is still in its early stages (as understood from various research publications and scientific databases like PubChem).
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Frequently asked
Sources referenced
* PubChem
* National Institutes of Health (NIH) Office of Dietary Supplements
* Mayo Clinic
* Various peer-reviewed scientific journals for preclinical research (e.g., metabolism, pharmacology journals)
* DrugBank (for general drug information principles)
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.