Dexmethylphenidate, often known by its brand name Focalin, is a central nervous system (CNS) stimulant medication. It is primarily prescribed for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in both children and adults. It is the d-threo-isomer of methylphenidate, meaning it is one of the two mirror-image molecules (enantiomers) that make up racemic methylphenidate. Dexmethylphenidate is considered the more pharmacologically active component of methylphenidate. It is available in immediate-release and extended-release formulations. As a controlled substance, its use is regulated due to its potential for abuse and dependence. (FDA label, DrugBank)
Deep dive
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Frequently asked
Sources referenced
["FDA label for Focalin and Focalin XR", "MedlinePlus - Dexmethylphenidate", "PubChem - Dexmethylphenidate", "DrugBank - Dexmethylphenidate", "Journal of the American Academy of Child and Adolescent Psychiatry (example journal type for evidence)"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.