Lisdexamfetamine, commonly known by its brand name Vyvanse, is a central nervous system (CNS) stimulant medication. It is a prodrug of dextroamphetamine, meaning it is inactive until it is metabolized in the body into its active form. Lisdexamfetamine is primarily prescribed for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in adults and children aged 6 and older, and for moderate to severe Binge Eating Disorder (BED) in adults.
As a controlled substance, its use is regulated due to its potential for abuse and dependence. The medication is taken orally and is available in capsule and chewable tablet forms. Its unique prodrug nature contributes to a smoother and longer-lasting effect compared to immediate-release stimulants, as the conversion to dextroamphetamine occurs gradually in the gastrointestinal tract and blood. (FDA label, DrugBank)
Deep dive
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Do not combine.
Compound-pair rule
Avoid
MAOI blocks catecholamine breakdown; combining with sympathomimetics can trigger hypertensive crisis.
Limit caffeine when using prescription stimulants; monitor blood pressure.
Compound-pair rule
Avoid
Yohimbine + stimulants sharply increases sympathetic tone and can trigger arrhythmia.
Do not combine.
Frequently asked
Sources referenced
* FDA (U.S. Food and Drug Administration)
* DrugBank
* PubChem
* NIH ODS (National Institutes of Health Office of Dietary Supplements)
* Mayo Clinic
* MedlinePlus
* Cochrane Library
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
