Lisinopril is a medication belonging to a class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is primarily used to treat high blood pressure (hypertension), heart failure, and to improve survival after a heart attack. Lisinopril works by relaxing blood vessels, which allows blood to flow more easily and lowers blood pressure. It is available as an oral tablet and is a commonly prescribed medication. (Mayo Clinic, MedlinePlus)
Deep dive
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Known interactions
Compound-pair rule
Caution
ACE inhibitors like lisinopril can raise potassium; adding potassium supplements can push it too high.
Don't add potassium without provider guidance and monitoring.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Compound-pair rule
Caution
PDE5 inhibitors add to the blood-pressure-lowering effect of antihypertensives.
Start PDE5 at the lowest effective dose and monitor for hypotension.
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
