Zinc is an essential trace mineral that plays a crucial role in numerous physiological processes in the human body. It is involved in catalytic, structural, and regulatory functions. As a cofactor for over 300 enzymes, it contributes to metabolism, DNA synthesis, protein synthesis, and cell division. Zinc is also vital for immune function, wound healing, and maintaining the senses of taste and smell. The body does not produce zinc, so it must be obtained through diet or supplementation. Dietary sources include red meat, poultry, seafood (especially oysters), dairy products, nuts, legumes, and fortified cereals. Deficiencies can lead to a variety of health problems, particularly affecting growth, immune response, and neurological function. (NIH ODS, PubChem)
Deep dive
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Known interactions
Compound-pair rule
Caution
High-dose calcium can reduce zinc absorption taken at the same time.
Separate by 2 hours if both are high-dose.
Suggested separation: 2 h
Compound-pair rule
Note
Ongoing high zinc intake can lower copper because they compete for absorption.
If supplementing zinc long-term, watch copper; many people balance the two.
Compound-pair rule
Caution
Divalent cations chelate levothyroxine in the gut and reduce absorption by up to 30%.
Take levothyroxine on empty stomach; separate mineral supplements by at least 4 hours.
Suggested separation: 4 h
Compound-pair rule
Caution
Divalent cations chelate levothyroxine in the gut and reduce absorption by up to 30%.
Take levothyroxine on empty stomach; separate mineral supplements by at least 4 hours.
Suggested separation: 4 h
Compound-pair rule
Caution
Divalent cations chelate levothyroxine in the gut and reduce absorption by up to 30%.
Take levothyroxine on empty stomach; separate mineral supplements by at least 4 hours.
Suggested separation: 4 h
Compound-pair rule
Caution
Divalent cations chelate levothyroxine in the gut and reduce absorption by up to 30%.
Take levothyroxine on empty stomach; separate mineral supplements by at least 4 hours.
Suggested separation: 4 h
Compound-pair rule
Note
High-dose zinc (>40 mg/day) long-term can lower copper status.
Include 1–2 mg copper daily when supplementing zinc >30 mg/day for extended periods.
Frequently asked
Sources referenced
["NIH Office of Dietary Supplements (ODS)","MedlinePlus","PubChem","Cochrane Library","Examine.com"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the mineral category or studied for the same goals.