Relaxin-2 is a peptide hormone, a naturally occurring biochemical compound composed of amino acid chains linked by peptide bonds. It is the most extensively studied member of the relaxin family of peptides. In humans, Relaxin-2 is primarily produced by reproductive organs, especially during pregnancy in the corpus luteum, placenta, and decidua. However, it is also expressed in other tissues, including the heart, brain, and kidneys, suggesting broader physiological roles beyond reproduction (PubChem, NIH ODS). Its primary function is associated with collagen remodeling, angiogenesis (formation of new blood vessels), and anti-inflammatory processes.
Historically, relaxins were first identified for their role in facilitating parturition (childbirth) by relaxing the pubic symphysis and softening the cervix. Subsequent research has unveiled a more extensive range of actions for Relaxin-2, particularly its involvement in connective tissue metabolism, systemic hemodynamics, and protection against fibrosis in various organs. Due to its multifaceted biological activities, Relaxin-2 has garnered interest for its potential therapeutic applications in conditions characterized by fibrosis, inflammation, and tissue remodeling (DrugBank). Its half-life in the human body is approximately 8 hours, meaning it takes about 8 hours for half of the administered substance to be eliminated from the bloodstream.
Deep dive
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Known interactions
Category rule: peptide × hormone
Note
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
Frequently asked
Sources referenced
["National Institutes of Health (NIH) Office of Dietary Supplements (ODS)","MedlinePlus (NIH)","PubChem (NIH)","Mayo Clinic","DrugBank","Cochrane Library","Examine.com"]
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Related compounds
Others in the peptide category or studied for the same goals.