Resveratrol is a natural polyphenol produced by several plants, including grapes, blueberries, raspberries, mulberries, and peanuts. It is often concentrated in the skin of red grapes and is also found in red wine. Resveratrol gained significant attention due to early studies suggesting it may contribute to the "French paradox" – the observation of relatively low rates of heart disease in France despite a diet high in saturated fats, potentially linked to red wine consumption (Source: NIH ODS). It exists in two main isomeric forms, *cis*- and *trans*-resveratrol, with *trans*-resveratrol being the more commonly studied and biologically active form (Source: PubChem).
As a supplement, resveratrol is typically extracted from plants like Japanese knotweed (*Polygonum cuspidatum*) or synthesized. Research interest in resveratrol spans various areas, including its antioxidant, anti-inflammatory, and potential longevity-promoting properties. While preclinical studies have shown promising results, large-scale human clinical trials are ongoing to fully understand its efficacy and applications (Source: Examine.com).
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
