supplement

L-Tryptophan

Chemical structure of L-Tryptophan (PubChem CID 6305)
Structure via PubChem
Half-life
2.5 h
Typical timing
bedtime
Food rule
either
Default unit
mg

Studied for

Overview

L-Tryptophan is an essential amino acid, meaning it cannot be synthesized by the human body and must be obtained through diet. It plays a critical role as a metabolic precursor, particularly in the biosynthesis of several important compounds including serotonin, melatonin, and niacin (vitamin B3). As a building block for proteins, L-Tryptophan is involved in numerous physiological processes. In the body, L-Tryptophan is converted to 5-hydroxytryptophan (5-HTP), which is then converted to serotonin. Serotonin is a neurotransmitter that influences mood, sleep, appetite, and other functions. Serotonin can then be converted into melatonin, a hormone that regulates the sleep-wake cycle. Due to these metabolic pathways, L-Tryptophan has been investigated for its potential role in supporting mood, sleep quality, and overall well-being. (PubChem, NIH ODS)

Deep dive

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Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

  • Compound-pair rule
    Caution

    Additional serotonin precursor with an SSRI/SNRI can push serotonin too high.

    Do not combine without a prescribing clinician's guidance.

  • Compound-pair rule
    Caution

    Additional serotonin precursor with an SSRI/SNRI can push serotonin too high.

    Do not combine without a prescribing clinician's guidance.

  • Compound-pair rule
    Caution

    Additional serotonin precursor with an SSRI/SNRI can push serotonin too high.

    Do not combine without a prescribing clinician's guidance.

  • Compound-pair rule
    Caution

    Additional serotonin precursor with an SSRI/SNRI can push serotonin too high.

    Do not combine without a prescribing clinician's guidance.

  • Compound-pair rule
    Caution

    Additional serotonin precursor with an SSRI/SNRI can push serotonin too high.

    Do not combine without a prescribing clinician's guidance.

Frequently asked

Sources referenced

["PubChem", "NIH Office of Dietary Supplements (ODS)", "MedlinePlus", "Cochrane Library", "Mayo Clinic", "DrugBank"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

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Related benefits

Other compounds studied for the same benefits as L-Tryptophan.

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