Ashwagandha (scientific name: *Withania somnifera*) is an ancient medicinal herb known for its adaptogenic properties. It is commonly used in Ayurvedic medicine, a traditional system of medicine from India. The plant is a small shrub with yellow flowers, native to India and North Africa. Extracts or powder from the plant's root or leaves are used for various health purposes. Ashwagandha is often classified as an adaptogen, meaning it is believed to help the body manage stress. Adaptogens are non-toxic plants that are proposed to help the body resist various stressors, whether physical, chemical, or biological. (NIH National Center for Complementary and Integrative Health).
The term 'ashwagandha' literally translates to 'smell of the horse,' referring both to its unique scent and its traditional association with imparting the strength and vitality of a horse. It has been used for thousands of years to support overall health and well-being. Modern scientific inquiry has begun to explore the traditional uses of this herb, focusing on its potential effects on stress, anxiety, cognitive function, and other areas of health. (Examine.com)
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Compound-pair rule
Note
Ashwagandha can raise T4/T3 levels and may amplify thyroid medication effect.
Monitor TSH when starting ashwagandha on levothyroxine.
Compound-pair rule
Note
Additive sedation possible.
Use lower doses when combined.
Frequently asked
Sources referenced
* Cochrane Library
* DrugBank
* Examine.com
* Mayo Clinic
* MedlinePlus
* NIH National Center for Complementary and Integrative Health
* NIH National Library of Medicine
* NIH Office of Dietary Supplements (ODS)
* PubChem
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.