supplement

Huperzine A

Chemical structure of Huperzine A (PubChem CID 854026)
Structure via PubChem
Half-life
12 h
Typical timing
morning
Food rule
either
Default unit
mcg

Studied for

Overview

Huperzine A is a naturally occurring sesquiterpene alkaloid compound derived from the Chinese club moss, *Huperzia serrata*. This plant has a long history of use in traditional Chinese medicine for conditions including fever, inflammation, and memory impairment. In modern contexts, Huperzine A is primarily investigated and used as a dietary supplement for its potential cognitive-enhancing properties. It is available in various over-the-counter formulations, often marketed for memory, focus, and overall brain health. Studies have explored its role in neurodegenerative conditions, although more definitive research is needed before any medical claims can be made. (PubChem, NIH ODS)

Deep dive

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Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

Frequently asked

Sources referenced

["Cochrane Library", "DrugBank", "Mayo Clinic", "MedlinePlus", "NIH Office of Dietary Supplements (ODS)", "PubChem"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

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Related benefits

Other compounds studied for the same benefits as Huperzine A.

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