supplement

CDP-Choline

Also known as: Citicoline

Chemical structure of CDP-Choline (PubChem CID 13804)
Structure via PubChem
Half-life
56 h
Typical timing
morning
Food rule
either
Default unit
mg

Studied for

Overview

CDP-Choline, also known as Citicoline, is an endogenous compound found naturally in the body. It plays a crucial role in cell membrane synthesis and neuronal function. As a supplement, it is often marketed for its potential cognitive-enhancing properties, particularly in areas related to memory, focus, and overall brain health. CDP-Choline is a psychostimulant/nootropic that acts as an intermediate in the biosynthesis of phosphatidylcholine, a major component of neuronal cell membranes. It is composed of cytidine and choline, which are released upon oral intake and then recombine in the brain to form CDP-Choline (NIH ODS). It is available as an over-the-counter supplement, typically in capsule or powder form.

Deep dive

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Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

  • Compound-pair rule
    Synergy

    Choline supports acetylcholine turnover boosted by the racetam.

    Stack CDP-choline 250–500 mg with oxiracetam.

Frequently asked

Sources referenced

["NIH Office of Dietary Supplements (https://ods.od.nih.gov/)", "MedlinePlus (National Library of Medicine - https://medlineplus.gov/)", "PubChem (National Library of Medicine - https://pubchem.ncbi.nlm.nih.gov/)", "Mayo Clinic (https://www.mayoclinic.org/)", "Cochrane Library (https://www.cochranelibrary.com/)", "DrugBank (https://go.drugbank.com/)"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

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Related benefits

Other compounds studied for the same benefits as CDP-Choline.

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