medication

Allopurinol

Also known as: Zyloprim

Chemical structure of Allopurinol (PubChem CID 135401907)
Structure via PubChem
Half-life
1.5 h
Typical timing
with_meal
Food rule
with food
Default unit
mg

Overview

Allopurinol is a medication primarily used to reduce high levels of uric acid in the blood. Uric acid is a natural waste product formed during the breakdown of purines, which are found in many foods and are also produced by the body. When uric acid levels become too high, it can lead to various conditions, most notably gout and certain types of kidney stones. Gout is a form of inflammatory arthritis characterized by sudden, severe attacks of pain, redness, tenderness, and swelling in the joints, often the big toe. Allopurinol works by inhibiting an enzyme responsible for uric acid production. Allopurinol is available in oral tablet form and is categorized as a xanthine oxidase inhibitor. It is not typically used to treat acute gout attacks, but rather as a long-term preventive measure to lower uric acid levels and reduce the frequency and severity of future attacks. It is also used to prevent high uric acid levels (hyperuricemia) in people undergoing chemotherapy for certain cancers, as chemotherapy can cause a rapid breakdown of cells, leading to a sudden increase in uric acid. (Source: MedlinePlus, DrugBank)

Deep dive

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Known interactions

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

  • Category rule: vitamin × medication
    Note

    Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).

    Specific pairs are checked against a licensed source; confirm with your provider.

Frequently asked

Sources referenced

- Cochrane Library - DrugBank - Examine.com - FDA label (US Food and Drug Administration) - Mayo Clinic - MedlinePlus - NIH Office of Dietary Supplements (ODS) - PubChem

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

Others in the medication category or studied for the same goals.

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