Metformin extended-release (ER), also known by its brand name Glucophage XR, is an oral medication primarily used to manage blood glucose levels in adults and some children with type 2 diabetes. It belongs to a class of drugs called biguanides. Unlike some other diabetes medications, Metformin ER does not typically cause hypoglycemia (low blood sugar) when used alone. It works by improving how the body handles insulin and reducing the production of glucose by the liver. Beyond its primary use for diabetes, Metformin ER is also being investigated for its potential role in longevity and weight management due to its metabolic effects. The extended-release formulation allows for once-daily dosing, which can improve patient adherence compared to the immediate-release version. (NIH ODS, FDA label)
Deep dive
Tap a section to expand.
Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Note
Long-term metformin use is associated with reduced B12 absorption.
Monitor B12 annually; supplement if low.
Frequently asked
Sources referenced
["National Institutes of Health (NIH) Office of Dietary Supplements (ODS)", "MedlinePlus (National Library of Medicine)", "PubChem (National Library of Medicine)", "Mayo Clinic", "U.S. Food and Drug Administration (FDA) label for Metformin ER", "European Medicines Agency (EMA) Summary of Product Characteristics (SmPC)", "Cochrane Library", "DrugBank"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.