7-Keto DHEA, also known as 7-oxo-dehydroepiandrosterone, is a natural metabolite of the hormone dehydroepiandrosterone (DHEA). Unlike DHEA, 7-Keto DHEA is not converted by the body into steroid hormones such as androgens or estrogens. This characteristic is often highlighted because it may offer some of DHEA's potential benefits without the associated hormonal side effects. It is found naturally in the body, primarily produced by the adrenal glands and, to a lesser extent, the skin and brain. As individuals age, the natural production of DHEA and its metabolites, including 7-Keto DHEA, tends to decline.
7-Keto DHEA is commonly sold as a dietary supplement. It has been investigated for its potential role in various physiological processes, particularly those related to metabolism and immune function. The compound itself is involved in the thermogenic processes of the body, which produce heat and expend energy. Research interest in 7-Keto DHEA often focuses on its influence on basal metabolic rate and body composition, as well as its immunomodulatory effects. Understanding its distinct metabolic pathway, which avoids direct conversion to sex steroids, is key to differentiating it from DHEA.
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Sources referenced
["Examine.com","NIH Office of Dietary Supplements (ODS)","MedlinePlus","PubChem","Mayo Clinic"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
