peptide

Larazotide

Also known as: AT-1001

Chemical structure of Larazotide (PubChem CID 9810532)
Structure via PubChem
Half-life
1 h
Typical timing
with_meal
Food rule
with food
Default unit
mg

Studied for

Overview

Larazotide, also known by its development code AT-1001, is an orally administered peptide compound. It is being investigated for its potential role in managing conditions characterized by increased intestinal permeability, often referred to as "leaky gut." Larazotide is designed to block the functional activity of zonulin, a human protein that modulates intestinal tight junctions. By doing so, it aims to reduce the passage of undigested food particles, toxins, and microbes from the gut lumen into the bloodstream. Currently, larazotide is an investigational compound and is not approved for clinical use by regulatory bodies such as the FDA or EMA. Its development has primarily focused on celiac disease, where increased intestinal permeability is a prominent feature.

Deep dive

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Known interactions

  • Category rule: peptide × hormone
    Note

    Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.

    Track bloodwork with a provider; don't assume combinations are neutral.

Frequently asked

Sources referenced

["DrugBank Online", "PubChem (National Library of Medicine)", "NIH Office of Dietary Supplements (referencing general information on peptides and gut health)", "Cochrane Database of Systematic Reviews", "ClinicalTrials.gov (for study information)"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

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Related benefits

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