Duloxetine is a medication primarily used to treat major depressive disorder, generalized anxiety disorder, and chronic musculoskeletal pain, including fibromyalgia and chronic low back pain. It is also approved for diabetic peripheral neuropathic pain and chronic osteoarthritis pain. Duloxetine belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs). (NIH ODS)
Duloxetine is available in delayed-release capsule form and is typically taken orally. The specific dosage and treatment duration are determined by a licensed clinician based on the individual's condition and response to therapy. (FDA label for Duloxetine)
Deep dive
Tap a section to expand.
Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Avoid
Combining SSRIs/SNRIs with MAOIs can cause life-threatening serotonin syndrome.
Do not combine. Allow at least 14 days between stopping one and starting the other (5 weeks for fluoxetine).
Compound-pair rule
Avoid
Combining SSRIs/SNRIs with MAOIs can cause life-threatening serotonin syndrome.
Do not combine. Allow at least 14 days between stopping one and starting the other (5 weeks for fluoxetine).
Compound-pair rule
Avoid
Combining SSRIs/SNRIs with MAOIs can cause life-threatening serotonin syndrome.
Do not combine. Allow at least 14 days between stopping one and starting the other (5 weeks for fluoxetine).
Compound-pair rule
Avoid
Combining SSRIs/SNRIs with MAOIs can cause life-threatening serotonin syndrome.
Do not combine. Allow at least 14 days between stopping one and starting the other (5 weeks for fluoxetine).
Compound-pair rule
Avoid
5-HTP raises serotonin and layered onto an SSRI/SNRI risks serotonin syndrome.
Avoid combining 5-HTP with prescription serotonergic antidepressants.
Compound-pair rule
Caution
Additional serotonin precursor with an SSRI/SNRI can push serotonin too high.
Do not combine without a prescribing clinician's guidance.
Compound-pair rule
Avoid
St John's Wort has serotonergic activity and induces CYP3A4, altering SSRI levels.
Avoid combining.
Frequently asked
Sources referenced
["NIH ODS (National Institutes of Health Office of Dietary Supplements)", "MedlinePlus (National Library of Medicine)", "PubChem (National Library of Medicine)", "FDA label for Duloxetine (U.S. Food and Drug Administration)", "Mayo Clinic", "Cochrane Library", "DrugBank", "EMA SmPC (European Medicines Agency Summary of Product Characteristics)"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
