D-Aspartic Acid (DAA), also known as D-Aspartate, is a non-essential amino acid naturally found in the human body, particularly in the brain, neuroendocrine tissues, and testes. It is one of the two enantiomers of aspartic acid, the other being L-aspartic acid, which is a component of many proteins. DAA plays various roles in the nervous and endocrine systems, including the regulation of hormone synthesis and release.
As a supplement, DAA gained attention for its potential to increase testosterone levels, particularly in men with suboptimal levels, and to support muscle growth and strength. It is commonly marketed towards athletes and bodybuilders. While DAA is naturally present in some foods, such as corn, soy, and dairy products, the concentrations found in supplements are typically much higher than what can be obtained through diet alone. DAA is usually taken orally, often in powder or capsule form. (PubChem)
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Frequently asked
Sources referenced
["PubChem. D-Aspartic Acid.", "DrugBank. D-Aspartic Acid.", "National Institutes of Health (NIH) Office of Dietary Supplements (ODS).", "Cochrane Library. (Relevant reviews on testosterone/muscle enhancers).", "Journal of the International Society of Sports Nutrition.", "Reproductive Biology and Endocrinology.", "European Food Safety Authority (EFSA) Panel on Dietetic Products, Nutrition and Allergies (NDA)."]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.