hormone
Cardarine
Also known as: GW-501516
Half-life
24 h
Typical timing
any
Food rule
either
Default unit
mg
Studied for
Overview
Cardarine, also known as GW-501516 or Endurobol, is a research chemical that gained attention for its potential investigational properties related to endurance, fat metabolism, and muscle protection. It is classified as a peroxisome proliferator-activated receptor delta (PPAR-delta) agonist. This means it binds to and activates the PPAR-delta receptor, which is found in many tissues throughout the body, including muscle, liver, and adipose tissue. Activation of this receptor plays a role in cellular processes involved in energy metabolism.
Initially developed in the 1990s as a potential treatment for metabolic diseases like obesity, diabetes, and cardiovascular diseases, Cardarine's development was halted in 2007 due to safety concerns identified in animal studies. Despite its discontinuation in pharmaceutical development, Cardarine continues to be used in research settings and has been, at times, illicitly marketed and used in sports for its purported performance-enhancing effects.
It is important to understand that Cardarine is not approved for human use as a drug or dietary supplement by regulatory bodies such as the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA). Its use outside of a controlled research environment carries significant risks.
Deep dive
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Known interactions
- Category rule: peptide × hormoneNote
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
Frequently asked
Sources referenced
- PubChem (National Library of Medicine)
- DrugBank
- World Anti-Doping Agency (WADA)
- National Institutes of Health (NIH) Office of Dietary Supplements (ODS) - general information on research chemicals
- European Medicines Agency (EMA) - regulatory status of unapproved compounds
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
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Related benefits
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Endurance & Performance
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