Citrulline Malate is a dietary supplement often used to enhance athletic performance and support cardiovascular health. It is a combination of L-citrulline, a non-essential amino acid, and malate, a dicarboxylic acid that plays a role in the citric acid cycle. While L-citrulline can be found naturally in foods like watermelon, the supplemental form, particularly Citrulline Malate, is used to deliver higher concentrations for specific physiological effects. Once ingested, L-citrulline is converted to L-arginine in the kidneys, which then serves as a precursor for nitric oxide (NO) production. Nitric oxide is a potent vasodilator, meaning it helps to relax and widen blood vessels, potentially improving blood flow. The malate component is believed to support energy production, although its precise contribution in the context of Citrulline Malate's overall effects is still an area of ongoing research. It is commonly taken as a pre-workout supplement. (MedlinePlus, PubChem)
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
