Cagrilintide is an investigational drug, currently in clinical development, that is being studied for its potential role in weight management. It is designed as an amylin analogue, meaning it shares structural and functional similarities with amylin, a naturally occurring hormone. Amylin is co-secreted with insulin from pancreatic beta cells in response to food intake and plays a role in glucose homeostasis and satiety. Cagrilintide also functions as a glucagon-like peptide-1 (GLP-1) receptor agonist.
The combined actions of an amylin analogue and a GLP-1 receptor agonist are hypothesised to provide a synergistic effect on weight loss. Amylin's physiological actions include slowing gastric emptying, suppressing postprandial glucagon secretion, and promoting satiety. GLP-1 receptor agonism also slows gastric emptying, reduces appetite, and improves glycemic control, leading to reduced food intake and subsequent weight loss. Cagrilintide is administered via subcutaneous injection.
Clinical trials are underway to evaluate its efficacy and safety in individuals with obesity or overweight with comorbidities. This compound is not yet approved by regulatory bodies like the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA) for clinical use. Information presented here is based on publicly available data from clinical trials and research, primarily from the developer and scientific publications.
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Frequently asked
Sources referenced
["NIH Office of Dietary Supplements (ODS)", "MedlinePlus", "PubChem", "DrugBank", "Clinical trial publications (e.g., specific medical journals like JAMA, New England Journal of Medicine)", "Developer's official press releases and scientific presentations"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the glp1 category or studied for the same goals.