Vitamin K2 MK-7, also known as menaquinone-7, is a lipid-soluble vitamin that plays a crucial role in several physiological processes, primarily involving calcium regulation within the body. It is one of several forms of vitamin K2, which itself is a subgroup of the broader vitamin K family. While vitamin K1 (phylloquinone) is predominantly found in green leafy vegetables and is well-known for its role in blood clotting, vitamin K2 (menaquinones) is found in fermented foods and animal products, and is more recognized for its contributions to bone and cardiovascular health. MK-7 is a long-chain menaquinone, distinguishing it from shorter-chain menaquinones like MK-4. Its longer half-life (approximately 72 hours) compared to MK-4 allows for more stable and sustained levels in the bloodstream, contributing to its effectiveness in activating specific proteins. The interest in vitamin K2 MK-7 has grown significantly due to research suggesting its involvement in directing calcium to appropriate tissues, such as bones, and away from soft tissues, like arteries. This selective calcium handling is thought to be a key mechanism behind its proposed benefits for skeletal integrity and arterial flexibility. As a dietary supplement, MK-7 is commonly derived from natto, a traditional Japanese fermented soybean dish, or produced synthetically. (NIH ODS, PubChem)
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Known interactions
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Synergy
K2 (MK-7) directs D3-mobilized calcium into bone.
Take D3 and MK-7 together with fat.
Frequently asked
Sources referenced
* NIH Office of Dietary Supplements (ODS)
* MedlinePlus
* PubChem
* Mayo Clinic
* FDA Drug Label Information
* EMA Summary of Product Characteristics (SmPC)
* Cochrane Library
* Examine.com
* DrugBank
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the vitamin category or studied for the same goals.