Trazodone is an antidepressant medication that belongs to the class of serotonin antagonist and reuptake inhibitors (SARIs). It is primarily approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder. Due to its significant sedative properties, trazodone is also frequently used off-label to help manage insomnia, particularly in individuals who experience difficulty falling or staying asleep (Source: FDA label, DrugBank).
Chemically, trazodone hydrochloride is a triazolopyridine derivative. Its effects are thought to be mediated through its interactions with various neurotransmitter systems in the brain. While beneficial for mood and sleep, it is important to understand its therapeutic profile, potential side effects, and interactions.
Individual responses to trazodone can vary, and its use should always be guided by a licensed healthcare professional. It is typically available in oral tablet form and is taken by mouth.
Deep dive
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Note
Additive sedation possible.
Start at low melatonin dose (0.3–1 mg) when combined with prescription sedatives.
Frequently asked
Sources referenced
["U.S. Food and Drug Administration (FDA) label for Trazodone","DrugBank","PubChem","Mayo Clinic","MedlinePlus","Cochrane Reviews"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.