TA-65 is a proprietary dietary supplement containing a purified extract from the *Astragalus membranaceus* plant. The active ingredient in TA-65 is identified as cycloastragenol, a triterpenoid saponin. *Astragalus membranaceus* has a long history of use in traditional Chinese medicine for various conditions, often associated with promoting vitality and supporting immune function. Cycloastragenol itself is derived from astragalosides, which are another group of compounds found in the *Astragalus* root.
The supplement is marketed primarily for its potential role in cellular aging, specifically through its purported impact on telomeres. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. Telomere shortening is considered a hallmark of cellular aging, and an enzyme called telomerase can help maintain or even extend telomere length. TA-65's mechanism of action is often discussed in relation to telomerase activation.
TA-65 is available as an oral capsule. It is classified as a dietary supplement and is not regulated as a drug by agencies like the U.S. Food and Drug Administration (FDA). Information regarding its efficacy and safety primarily comes from preclinical studies, some human observational studies, and research supported by the supplement's manufacturers or distributors. (Source: PubChem, Examine.com)
Deep dive
Tap a section to expand.
Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Sources referenced
* PubChem (National Library of Medicine)
* Examine.com
* NIH Office of Dietary Supplements (ODS)
* MedlinePlus (National Library of Medicine)
* Cochrane Library (for principles of evidence evaluation)
* U.S. Food and Drug Administration (FDA) (for supplement regulation principles)
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
