supplement

Sulforaphane

Also known as: Broccoli extract

Chemical structure of Sulforaphane (PubChem CID 5350)
Structure via PubChem
Half-life
6 h
Typical timing
morning
Food rule
either
Default unit
mg

Studied for

Overview

Sulforaphane is a sulfur-containing organic compound found primarily in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. It is part of a class of compounds called isothiocyanates. While sulforaphane itself is not directly present in these vegetables in large quantities, its precursor, glucoraphanin, is abundant. When glucoraphanin-rich vegetables are chopped, chewed, or digested, an enzyme called myrosinase is released. Myrosinase then acts on glucoraphanin to convert it into sulforaphane. This conversion process is crucial for the compound's bioavailability and activity within the body (PubChem, NIH ODS). Sulforaphane has garnered significant scientific interest due to its diverse biological activities. Research has explored its potential roles in various physiological processes, including antioxidant defense, inflammation modulation, and cellular detoxification. It is often studied in the context of general health maintenance and promoting cellular resilience. The compound is available as a dietary supplement, often derived from broccoli sprouts, which are particularly rich in glucoraphanin. Understanding how sulforaphane is formed and interacts with biological systems is key to appreciating its potential health implications.

Deep dive

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Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

Frequently asked

Sources referenced

* NIH Office of Dietary Supplements (ODS) * PubChem * MedlinePlus * Examine.com * Cochrane Database of Systemic Reviews

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

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Related benefits

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