Spironolactone, also known by its brand name Aldactone, is a medication classified as a potassium-sparing diuretic. It is primarily used to treat conditions such as heart failure, high blood pressure (hypertension), and edema (fluid retention) resulting from various causes like cirrhosis of the liver or nephrotic syndrome. It is also used in the management of primary aldosteronism, a condition characterized by excessive production of aldosterone by the adrenal glands, and off-label for certain dermatological conditions like acne and androgenic alopecia in women. This medication works by blocking the action of aldosterone, a hormone that regulates salt and water balance in the body. By doing so, spironolactone helps the body eliminate excess water and sodium while retaining potassium, which is distinct from many other diuretics that can cause potassium loss. (Mayo Clinic, DrugBank)
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Sources referenced
- Mayo Clinic
- NIH Office of Dietary Supplements (NIH ODS)
- MedlinePlus
- PubChem
- DrugBank
- Cochrane Library
- Examine.com
- FDA label (Spironolactone)
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
