Serelaxin is a recombinant form of human relaxin-2, a naturally occurring peptide hormone structurally related to insulin. In humans, relaxin-2 is primarily known for its roles in the female reproductive system, particularly during pregnancy and childbirth, where it mediates connective tissue remodeling and vasodilation. Serelaxin was developed as an investigational drug for the treatment of acute heart failure (AHF). Its physiological effects include vasodilation, anti-fibrotic activity, and anti-inflammatory properties. These actions are mediated through its interaction with relaxin family peptide receptor 1 (RXFP1), primarily found in the heart, kidneys, and blood vessels. The peptide's half-life in the human body is approximately 8 hours, requiring continuous intravenous administration in clinical studies (DrugBank, PubChem).
Deep dive
Tap a section to expand.
Known interactions
Category rule: peptide × hormone
Note
Injectable peptides plus hormones can have overlapping or compounding effects that aren't always well characterized.
Track bloodwork with a provider; don't assume combinations are neutral.
Frequently asked
Sources referenced
["Cochrane Library","ClinicalTrials.gov","DrugBank","European Medicines Agency (EMA) Public Assessment Reports","PubChem","U.S. Food and Drug Administration (FDA) Review Documents"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the peptide category or studied for the same goals.