Mirtazapine is an antidepressant medication approved by the U.S. Food and Drug Administration (FDA) primarily for the treatment of major depressive disorder. It is also sometimes used off-label for other conditions like anxiety disorders, insomnia, and nausea, though these uses are not FDA-approved for mirtazapine. It belongs to a class of antidepressants known as noradrenergic and specific serotonergic antidepressants (NaSSAs).
Mirtazapine is available in tablet form and orally disintegrating tablets. It is typically taken once daily, often at bedtime due to its sedative effects, and can be taken with or without food. The brand name for mirtazapine is Remeron.
As with all antidepressant medications, the full therapeutic effects of mirtazapine may not be immediately apparent, often requiring several weeks of consistent use to achieve optimal symptom improvement. It is crucial to continue taking the medication as prescribed and to not discontinue it abruptly without consulting a healthcare professional.
Deep dive
Tap a section to expand.
Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Compound-pair rule
Note
Additive sedation possible.
Start at low melatonin dose (0.3–1 mg) when combined with prescription sedatives.
Frequently asked
Sources referenced
["U.S. Food and Drug Administration (FDA) prescribing information","MedlinePlus (National Library of Medicine)","PubChem (National Library of Medicine)","DrugBank Online","Mayo Clinic","Examine.com","Cochrane Library","NIH Office of Dietary Supplements (ODS)"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
