medication

Macimorelin

Chemical structure of Macimorelin (PubChem CID 9804938)
Structure via PubChem
Half-life
4 h
Typical timing
any
Food rule
either
Default unit
mg

Overview

Macimorelin is a synthetic non-peptide growth hormone secretagogue receptor (GHSR) agonist. It is approved for use in diagnosing adult growth hormone deficiency (AGHD). When administered orally, macimorelin stimulates the release of growth hormone (GH) from the pituitary gland. The primary clinical utility of macimorelin is to assess the functional integrity of the somatotropic axis, providing a diagnostic tool for AGHD. This condition can lead to various symptoms including altered body composition, reduced bone mineral density, and impaired quality of life. Traditional methods for diagnosing AGHD often involve complex and time-consuming stimulation tests, such as the insulin tolerance test (ITT), which carries risks and requires close medical supervision. Macimorelin offers a simpler, oral alternative to these more invasive tests. The diagnostic test involves measuring serum GH levels at specific time points after macimorelin administration. A peak GH level below a predefined cutoff indicates growth hormone deficiency. Its development represents a significant advancement in the diagnostic landscape for AGHD, offering improved convenience and safety for patients. (FDA label, EMA SmPC)

Deep dive

Tap a section to expand.

Known interactions

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

  • Category rule: vitamin × medication
    Note

    Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).

    Specific pairs are checked against a licensed source; confirm with your provider.

Frequently asked

Sources referenced

- U.S. Food and Drug Administration (FDA) label - European Medicines Agency (EMA) Summary of Product Characteristics (SmPC)

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

Others in the medication category or studied for the same goals.

Track Macimorelin in Stackwise

Add it to your stack. We'll schedule doses, check interactions against everything else you take, and remind you at the right time.

Sign up free →