Levocetirizine, also commonly known as Xyzal, is a second-generation antihistamine used to relieve symptoms associated with seasonal and perennial allergic rhinitis, as well as chronic idiopathic urticaria (hives). It is the (R)-enantiomer of cetirizine. As a second-generation antihistamine, it is designed to be less sedating than older, first-generation antihistamines while still effectively managing allergy symptoms such as sneezing, runny nose, itchy watery eyes, and itching. Levocetirizine works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It is available over-the-counter and by prescription in various forms, including tablets and oral solutions. (MedlinePlus, PubChem)
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Frequently asked
Sources referenced
["MedlinePlus", "PubChem", "FDA label (for Xyzal or Levocetirizine Dihydrochloride)", "DrugBank", "EMA SmPC (European Medicines Agency Summary of Product Characteristics)"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
