Hydrochlorothiazide (HCTZ) is a thiazide diuretic medication commonly used to treat high blood pressure (hypertension) and edema (fluid retention) caused by various conditions, including heart failure, liver cirrhosis, and kidney disorders. It functions by increasing the excretion of sodium and water from the body through the kidneys, which helps to reduce blood volume and consequently lower blood pressure and diminish swelling. HCTZ is often prescribed alone or in combination with other antihypertensive agents. It is available as an oral tablet. (FDA label, MedlinePlus)
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Frequently asked
Sources referenced
- DrugBank
- EMA SmPC (European Medicines Agency Summary of Product Characteristics)
- FDA label (U.S. Food and Drug Administration label)
- Mayo Clinic
- MedlinePlus
- NIH ODS (National Institutes of Health Office of Dietary Supplements)
- PubChem
- Cochrane
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
