Guanfacine is an alpha-2A adrenergic receptor agonist used in the management of Attention-Deficit/Hyperactivity Disorder (ADHD) and certain other conditions. It is available in both immediate-release and extended-release formulations. The extended-release formulation is marketed under the brand name Intuniv. Unlike some other ADHD medications, guanfacine is not a stimulant. It works by affecting specific receptors in the brain, which can help improve attention, reduce impulsivity, and manage hyperactivity. It is typically considered when stimulant medications are not tolerated, are ineffective, or when co-existing conditions, such as tic disorders, are present (FDA label). Guanfacine's mechanism differs from stimulants, offering an alternative approach to symptom management.
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Known interactions
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Category rule: vitamin × medication
Note
Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).
Specific pairs are checked against a licensed source; confirm with your provider.
Frequently asked
Sources referenced
* DrugBank
* U.S. Food and Drug Administration (FDA) label for Intuniv
* National Institutes of Health (NIH) National Library of Medicine (MedlinePlus)
* PubChem
* Cochrane Library
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the medication category or studied for the same goals.
