medication

Fluconazole

Also known as: Diflucan

Chemical structure of Fluconazole (PubChem CID 3365)
Structure via PubChem
Half-life
30 h
Typical timing
morning
Food rule
either
Default unit
mg

Overview

Fluconazole, also known by the brand name Diflucan, is an antifungal medication belonging to the azole class. It is primarily used to treat a variety of fungal infections throughout the body, including vaginal yeast infections, oral thrush (candidiasis of the mouth and throat), esophageal candidiasis, urinary tract infections, and serious systemic fungal infections like cryptococcal meningitis. Fluconazole is effective against specific types of fungi, particularly Candida species. It works by interfering with the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to increased permeability of the fungal cell membrane, ultimately inhibiting fungal growth and replication. Fluconazole is available in oral tablet, oral suspension, and intravenous forms. The specific formulation and dosage depend on the type and severity of the infection, as well as individual patient factors. It is generally well-absorbed after oral administration and distributes widely throughout the body, including into the cerebrospinal fluid, which makes it useful for treating fungal infections of the brain and spinal cord (per the NIH ODS Fluconazole Monograph).

Deep dive

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Known interactions

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

  • Category rule: vitamin × medication
    Note

    Certain vitamins interact with specific medications (e.g., vitamin K with blood thinners).

    Specific pairs are checked against a licensed source; confirm with your provider.

Frequently asked

Sources referenced

["U.S. National Library of Medicine, MedlinePlus", "National Institutes of Health, Office of Dietary Supplements (NIH ODS)", "PubChem", "DrugBank", "U.S. Food and Drug Administration (FDA) Prescribing Information (label)", "Cochrane Library", "European Medicines Agency (EMA) Summary of Product Characteristics (SmPC)"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

Others in the medication category or studied for the same goals.

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