supplement

Ergothioneine

Also known as: EGT

Chemical structure of Ergothioneine (PubChem CID 5351619)
Structure via PubChem
Half-life
720 h
Typical timing
morning
Food rule
either
Default unit
mg

Studied for

Overview

Ergothioneine (EGT) is a naturally occurring amino acid derivative that contains sulfur. It is found in various dietary sources, particularly mushrooms, and is unique in that mammals, including humans, have a specific transporter protein (OCTN1) for its uptake and accumulation in tissues. This suggests a crucial physiological role for EGT in the body. EGT is characterized by its potent antioxidant properties and its ability to protect cells from oxidative stress and damage. It is considered a 'cytoprotectant' due to its role in maintaining cellular health and function. EGT is not synthesized by humans and must be obtained through the diet. Its presence in high concentrations in certain tissues, such as the liver, kidneys, lens of the eye, and red blood cells, underscores its importance in organ protection and overall cellular integrity. Research into EGT has increased significantly due to its potential implications for aging, neurodegenerative diseases, and chronic inflammatory conditions.

Deep dive

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Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

Frequently asked

Sources referenced

["National Institutes of Health (NIH) Office of Dietary Supplements (ODS)", "MedlinePlus (U.S. National Library of Medicine)", "PubChem (National Library of Medicine)", "DrugBank (University of Alberta)", "The Cochrane Library"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

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Related benefits

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