Ergothioneine (EGT) is a naturally occurring amino acid derivative that contains sulfur. It is found in various dietary sources, particularly mushrooms, and is unique in that mammals, including humans, have a specific transporter protein (OCTN1) for its uptake and accumulation in tissues. This suggests a crucial physiological role for EGT in the body. EGT is characterized by its potent antioxidant properties and its ability to protect cells from oxidative stress and damage. It is considered a 'cytoprotectant' due to its role in maintaining cellular health and function.
EGT is not synthesized by humans and must be obtained through the diet. Its presence in high concentrations in certain tissues, such as the liver, kidneys, lens of the eye, and red blood cells, underscores its importance in organ protection and overall cellular integrity. Research into EGT has increased significantly due to its potential implications for aging, neurodegenerative diseases, and chronic inflammatory conditions.
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Frequently asked
Sources referenced
["National Institutes of Health (NIH) Office of Dietary Supplements (ODS)", "MedlinePlus (U.S. National Library of Medicine)", "PubChem (National Library of Medicine)", "DrugBank (University of Alberta)", "The Cochrane Library"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.