Spermidine is a naturally occurring polyamine compound found in all living organisms. It plays a critical role in various cellular processes, including cell growth, proliferation, differentiation, and apoptosis (programmed cell death). As we age, the body's natural production of spermidine may decline. It is also present in many foods, such as aged cheese, mushrooms, legumes, nuts, and whole grains, and is available as a dietary supplement. Interest in spermidine has grown due to research into its potential role in autophagy, a cellular process involving the body's natural way of cleaning out damaged cells to regenerate newer, healthier cells. (Source: PubChem, NIH ODS)
Deep dive
Tap a section to expand.
Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Sources referenced
* PubChem (National Library of Medicine)
* NIH Office of Dietary Supplements (ODS)
* Examine.com
* Mayo Clinic
* Cosmetics Europe
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
