Pterostilbene is a natural compound classified as a stilbenoid, a type of polyphenol. It is structurally similar to resveratrol, another well-known stilbenoid, but contains two methoxy groups in place of hydroxyl groups on one of the phenyl rings. This structural difference is thought to enhance its bioavailability and metabolic stability compared to resveratrol (PubChem). Pterostilbene is primarily found in plants, with significant concentrations observed in blueberries, cranberries, and the bark of the Pterocarpus marsupium tree.
The compound has garnered scientific interest due to its diverse biological activities in preclinical studies. Research has explored its potential roles in antioxidant defense, inflammation modulation, and cellular health (Examine.com). While research is ongoing, pterostilbene is available as a dietary supplement, often marketed for its potential contributions to overall wellness and healthy aging. The half-life of pterostilbene in humans is approximately 5 hours.
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Sources referenced
- PubChem
- NIH Office of Dietary Supplements (NIH ODS)
- MedlinePlus
- Mayo Clinic
- Examine.com
- Cochrane
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
