Methylsulfonylmethane (MSM) is an organosulfur compound with the chemical formula (CH3)2SO2. It is naturally present in some green plants, animals, and humans, and can also be manufactured synthetically for use as a dietary supplement (PubChem). MSM is a source of sulfur, an element that plays a role in the body's connective tissues, including cartilage and skin. It is commonly marketed and used as a supplement for various health purposes, particularly in relation to joint health and athletic recovery. While it is found in small amounts in a variety of foods, including fruits, vegetables, grains, and beverages like milk, tea, and coffee, the concentrations are generally low, leading some individuals to seek supplementation for higher intake. The supplement form is often a white, odorless crystalline powder (Examine.com).
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Sources referenced
* PubChem (National Library of Medicine)
* NIH Office of Dietary Supplements (ODS)
* MedlinePlus (National Library of Medicine)
* Examine.com
* Cochrane Library
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
