Bromelain refers to a group of enzymes derived from the pineapple plant (Ananas comosus). It is typically extracted from the fruit and stem of the pineapple. Historically, pineapple has been used in traditional medicine for centuries, particularly for its digestive and anti-inflammatory properties. Modern scientific interest in bromelain began in the late 19th and early 20th centuries, leading to its identification as a proteolytic enzyme blend. It is most commonly marketed as a dietary supplement that may aid in various health conditions, particularly those involving inflammation or swelling. It is recognized for its ability to break down proteins, a characteristic that underpins many of its purported biological effects. Bromelain is available in various forms, including capsules, tablets, and topical creams, and its activity is often measured in enzyme units such as GDU (gelatin dissolving units) or MCU (milk clotting units), which indicate its proteolytic strength. As an over-the-counter supplement, it is widely used by individuals seeking natural support for inflammation, recovery from injury or surgery, and digestive health. (National Institutes of Health Office of Dietary Supplements, MedlinePlus)
Deep dive
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Known interactions
Category rule: glp1 × supplement
Note
GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.
Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.
Category rule: supplement × medication
Note
Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).
Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.
Discuss with prescribing clinician; monitor for bruising, prolonged bleeding, and dose adjustments.
Frequently asked
Sources referenced
["PubChem (National Library of Medicine)","Examine.com","MedlinePlus (National Library of Medicine)","NIH ODS (Office of Dietary Supplements)","Cochrane Library","U.S. Food and Drug Administration (FDA Label for specific products)"]
Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.
Related compounds
Others in the supplement category or studied for the same goals.
