supplement

Fisetin

Chemical structure of Fisetin (PubChem CID 5281614)
Structure via PubChem
Half-life
Typical timing
with_meal
Food rule
with food
Default unit
mg

Studied for

Overview

Fisetin is a naturally occurring flavonoid, a type of plant pigment found in many fruits and vegetables. It is structurally similar to other well-known flavonoids like quercetin and kaempferol. Fisetin has garnered scientific interest primarily for its senolytic activity, meaning its ability to selectively induce programmed cell death (apoptosis) in senescent cells. Senescent cells, often referred to as 'zombie cells,' are aged cells that stop dividing but remain metabolically active, secreting inflammatory molecules that can contribute to aging-related diseases. Eliminating these cells is a key strategy being investigated in longevity research. (NIH ODS) Beyond its senolytic properties, fisetin also exhibits antioxidant, anti-inflammatory, and neuroprotective effects. It is commonly found in strawberries, apples, persimmons, onions, and cucumbers, with strawberries generally having the highest concentrations. While research on fisetin is ongoing, particularly in human clinical trials, its broad range of biological activities positions it as a compound with potential therapeutic applications in various health contexts, including cognitive function, metabolic health, and healthy aging. (PubChem)

Deep dive

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Known interactions

  • Category rule: glp1 × supplement
    Note

    GLP-1 medications slow stomach emptying, changing how/when oral supplements absorb; rapid weight loss raises the importance of protein and micronutrients.

    Time oral supplements when nausea is lowest; prioritize protein and micronutrients; discuss with your provider.

  • Category rule: supplement × medication
    Note

    Some supplements change how the body processes medications (absorption, liver enzymes, or additive effects).

    Specific pairs are checked against a licensed drug database and shown with their own severity. Always confirm with your provider or pharmacist.

Frequently asked

Sources referenced

["NIH Office of Dietary Supplements (ODS)", "PubChem (National Library of Medicine)", "MedlinePlus (National Library of Medicine)", "Cochrane Library", "DrugBank"]

Stackwise compiles summaries from publicly available scientific and regulatory references. Always verify important decisions with a licensed clinician.

Related compounds

Others in the supplement category or studied for the same goals.

Related benefits

Other compounds studied for the same benefits as Fisetin.

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